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Save the Vig - Biggest Upsets as of Week 13
A look at 2021's Biggest Upsets.

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(Oct 16)    The Louisiana Monroe Warhawks beat the Liberty Flames as a 32.5 point home underdog.
(Nov 13)    The Kansas Jayhawks beat the Texas Longhorns in their own house as a 31 point underdog.
(Sep 25)    The Bowling Green Falcons beat the Minnesota Golden Gophers in their own house as a 30.5 point underdog.
(Sep 11)    The Duquesne Dukes beat the Ohio Bobcats in their own house as a 28.5 point underdog.
(Sep 11)    The Jacksonville State Gamecocks beat the Florida State Seminoles in their own house as a 27.5 point underdog.
(Sep 18)    The Northern Arizona Lumberjacks beat the Arizona Wildcats in their own house as a 26.5 point underdog.
(Oct 23)    The Illinois Fighting Illini beat the Penn State Nittany Lions in their own house as a 24.5 point underdog.
(Sep 25)    The Louisiana Monroe Warhawks beat the Troy Trojans as a 23.5 point home underdog.
(Oct 23)    The Rice Owls beat the UAB Blazers in their own house as a 23.5 point underdog.
(Sep 4)    The Montana Grizzlies beat the Washington Huskies in their own house as a 22.5 point underdog.
(Sep 2)    The UC Davis Aggies beat the Tulsa Golden Hurricane in their own house as a 22 point underdog.
(Sep 4)    The East Tennessee State Buccaneers beat the Vanderbilt Commodores in their own house as a 21 point underdog.
(Nov 6)    The South Carolina Gamecocks beat the Florida Gators as a 20.5 point home underdog.
(Oct 23)    The New Mexico Lobos beat the Wyoming Cowboys in their own house as a 20 point underdog.
(Sep 4)    The Northern Illinois Huskies beat the Georgia Tech Yellow Jackets in their own house as a 19 point underdog.
(Oct 9)    The Texas A&M Aggies beat the Alabama Crimson Tide as a 18.5 point home underdog.
(Oct 9)    The Florida State Seminoles beat the North Carolina Tar Heels in their own house as a 17.5 point underdog.
(Sep 4)    The Utah State Aggies beat the Washington State Cougars in their own house as a 17.5 point underdog.
(Sep 11)    The Stanford Cardinal beat the USC Trojans in their own house as a 17 point underdog.
(Oct 30)    The Washington State Cougars beat the Arizona State Sun Devils in their own house as a 16.5 point underdog.
(Oct 2)    The Navy Midshipmen beat the UCF Knights as a 15.0 point home underdog.
(Nov 19)    The Southern Mississippi Golden Eagles beat the Louisiana Tech Bulldogs in their own house as a 15 point underdog.
(Sep 18)    The Colorado State Rams beat the Toledo Rockets in their own house as a 14.5 point underdog.
(Nov 6)    The Illinois Fighting Illini beat the Minnesota Golden Gophers in their own house as a 14.5 point underdog.
(Sep 11)    The Oregon Ducks beat the Ohio State Buckeyes in their own house as a 14.5 point underdog.
(Sep 18)    The Western Michigan Broncos beat the Pittsburgh Panthers in their own house as a 14 point underdog.
(Oct 9)    The Akron Zips beat the Bowling Green Falcons in their own house as a 14 point underdog.
(Oct 30)    The Bowling Green Falcons beat the Buffalo Bulls in their own house as a 13.5 point underdog.
(Oct 23)    The Louisiana Monroe Warhawks beat the South Alabama Jaguars as a 13.5 point home underdog.
(Nov 13)    The Texas Tech Red Raiders beat the Iowa State Cyclones as a 13.0 point home underdog.
(Oct 9)    The Ball State Cardinals beat the Western Michigan Broncos in their own house as a 13 point underdog.
(Oct 9)    The Northern Illinois Huskies beat the Toledo Rockets in their own house as a 13 point underdog.
(Oct 16)    The LSU Tigers beat the Florida Gators as a 12.5 point home underdog.
(Nov 13)    The Georgia State Panthers beat the Coastal Carolina Chanticleers in their own house as a 12.5 point underdog.
(Nov 6)    The Colorado Buffaloes beat the Oregon State Beavers as a 11.5 point home underdog.
(Oct 2)    The Temple Owls beat the Memphis Tigers as a 11.0 point home underdog.
(Oct 29)    The Navy Midshipmen beat the Tulsa Golden Hurricane in their own house as a 11 point underdog.
(Sep 18)    The East Carolina Pirates beat the Marshall Thundering Herd in their own house as a 11 point underdog.
(Sep 18)    The Fresno State Bulldogs beat the UCLA Bruins in their own house as a 11 point underdog.
(Sep 25)    The Oregon State Beavers beat the USC Trojans in their own house as a 11 point underdog.
(Oct 2)    The Middle Tennessee Blue Raiders beat the Marshall Thundering Herd as a 11.0 point home underdog.
(Oct 16)    The Purdue Boilermakers beat the Iowa Hawkeyes in their own house as a 11 point underdog.
(Sep 25)    The NC State Wolfpack beat the Clemson Tigers as a 10.5 point home underdog.
(Oct 2)    The Ball State Cardinals beat the Army Black Knights as a 10.5 point home underdog.
(Sep 18)    The Incarnate Word Cardinals beat the Texas State Bobcats in their own house as a 10.5 point underdog.
(Oct 2)    The Hawai'i Rainbow Warriors beat the Fresno State Bulldogs as a 10.5 point home underdog.

There have been 46 upsets by teams that were 10 point underdogs or more in the 2021 regular season.
Out of 443 games with spreads of 10 or higher, 46 teams, or 10.38% were able to pull off the outright victory.