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Save the Vig - Biggest Upsets as of Week 14
A look at 2022's Biggest Upsets.

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(Sep 24)    The Middle Tennessee Blue Raiders beat the Miami Hurricanes as a 25.5 point road underdog.
(Nov 26)    The New Mexico State Aggies beat the Liberty Flames as a 24 point road underdog.
(Sep 10)    The Georgia Southern Eagles beat the Nebraska Cornhuskers as a 23.5 point road underdog.
(Oct 1)    The Connecticut Huskies beat the Fresno State Bulldogs as a 23.5 point home underdog.
(Nov 19)    The South Carolina Gamecocks beat the Tennessee Volunteers as a 22.5 point home underdog.
(Oct 1)    The Georgia Tech Yellow Jackets beat the Pittsburgh Panthers as a 21.5 point road underdog.
(Nov 19)    The Georgia Tech Yellow Jackets beat the North Carolina Tar Heels as a 21.5 point road underdog.
(Sep 17)    The Eastern Michigan Eagles beat the Arizona State Sun Devils as a 20.5 point road underdog.
(Sep 10)    The Marshall Thundering Herd beat the Notre Dame Fighting Irish as a 20.5 point road underdog.
(Sep 17)    The Charlotte 49ers beat the Georgia State Panthers as a 19.5 point road underdog.
(Nov 12)    The Arizona Wildcats beat the UCLA Bruins as a 19.5 point road underdog.
(Oct 8)    The Texas State Bobcats beat the Appalachian State Mountaineers as a 19.5 point home underdog.
(Nov 12)    The Boston College Eagles beat the NC State Wolfpack as a 18 point road underdog.
(Sep 10)    The Appalachian State Mountaineers beat the Texas A&M Aggies as a 18 point road underdog.
(Sep 10)    The Washington State Cougars beat the Wisconsin Badgers as a 17.5 point road underdog.
(Nov 12)    The Vanderbilt Commodores beat the Kentucky Wildcats as a 17 point road underdog.
(Sep 17)    The Bowling Green Falcons beat the Marshall Thundering Herd as a 17.0 point home underdog.
(Sep 16)    The Wyoming Cowboys beat the Air Force Falcons as a 16.5 point home underdog.
(Oct 15)    The Stanford Cardinal beat the Notre Dame Fighting Irish as a 16.5 point road underdog.
(Nov 5)    The Michigan State Spartans beat the Illinois Fighting Illini as a 16.5 point road underdog.
(Sep 24)    The Navy Midshipmen beat the East Carolina Pirates as a 16.5 point road underdog.
(Sep 23)    The UTEP Miners beat the Boise State Broncos as a 16.0 point home underdog.
(Oct 15)    The Colorado Buffaloes beat the California Golden Bears as a 15.0 point home underdog.
(Oct 1)    The Florida International Golden Panthers beat the New Mexico State Aggies as a 15 point road underdog.
(Oct 29)    The Charlotte 49ers beat the Rice Owls as a 15 point road underdog.
(Nov 5)    The Liberty Flames beat the Arkansas Razorbacks as a 14.5 point road underdog.
(Nov 15)    The Bowling Green Falcons beat the Toledo Rockets as a 14.5 point road underdog.
(Nov 19)    The Navy Midshipmen beat the UCF Knights as a 14.5 point road underdog.
(Nov 19)    The Vanderbilt Commodores beat the Florida Gators as a 14.0 point home underdog.
(Nov 26)    The South Carolina Gamecocks beat the Clemson Tigers as a 14 point road underdog.
(Oct 22)    The Florida International Golden Panthers beat the Charlotte 49ers as a 14 point road underdog.
(Sep 10)    The Kansas Jayhawks beat the West Virginia Mountaineers as a 14 point road underdog.
(Nov 5)    The LSU Tigers beat the Alabama Crimson Tide as a 13.5 point home underdog.
(Oct 1)    The Boston College Eagles beat the Louisville Cardinals as a 13.5 point home underdog.
(Oct 8)    The Arizona State Sun Devils beat the Washington Huskies as a 13.5 point home underdog.
(Sep 10)    The Middle Tennessee Blue Raiders beat the Colorado State Rams as a 13.5 point road underdog.
(Sep 17)    The Southern Illinois Salukis beat the Northwestern Wildcats as a 13.5 point road underdog.
(Sep 17)    The Tulane Green Wave beat the Kansas State Wildcats as a 13.5 point road underdog.
(Sep 24)    The Kansas State Wildcats beat the Oklahoma Sooners as a 13.5 point road underdog.
(Nov 12)    The Louisiana Monroe Warhawks beat the Georgia State Panthers as a 13.5 point road underdog.
(Nov 12)    The Connecticut Huskies beat the Liberty Flames as a 13.5 point home underdog.
(Oct 15)    The Georgia Southern Eagles beat the James Madison Dukes as a 13.0 point home underdog.
(Sep 3)    The Delaware Blue Hens beat the Navy Midshipmen as a 13 point road underdog.
(Nov 26)    The Tulsa Golden Hurricane beat the Houston Cougars as a 13 point road underdog.
(Sep 24)    The Southern Mississippi Golden Eagles beat the Tulane Green Wave as a 12 point road underdog.
(Nov 12)    The Washington Huskies beat the Oregon Ducks as a 12 point road underdog.
(Nov 19)    The Indiana Hoosiers beat the Michigan State Spartans as a 12 point road underdog.
(Oct 8)    The Utah State Aggies beat the Air Force Falcons as a 11.5 point home underdog.
(Sep 17)    The Rice Owls beat the Louisiana Ragin' Cajuns as a 11.5 point home underdog.
(Nov 19)    The Hawai'i Rainbow Warriors beat the UNLV Rebels as a 11.0 point home underdog.
(Oct 15)    The Old Dominion Monarchs beat the Coastal Carolina Chanticleers as a 11 point road underdog.
(Nov 19)    The Virginia Tech Hokies beat the Liberty Flames as a 10.5 point road underdog.
(Oct 1)    The Rice Owls beat the UAB Blazers as a 10.5 point home underdog.
(Oct 12)    The Louisiana Ragin' Cajuns beat the Marshall Thundering Herd as a 10.5 point road underdog.
(Nov 25)    The Nebraska Cornhuskers beat the Iowa Hawkeyes as a 10.5 point road underdog.
(Nov 26)    The Texas A&M Aggies beat the LSU Tigers as a 10.0 point home underdog.
(Oct 22)    The Duke Blue Devils beat the Miami Hurricanes as a 10 point road underdog.
(Sep 10)    The Duke Blue Devils beat the Northwestern Wildcats as a 10 point road underdog.
(Oct 29)    The North Texas Mean Green beat the Western Kentucky Hilltoppers as a 10 point road underdog.
(Nov 16)    The Western Michigan Broncos beat the Central Michigan Chippewas as a 10 point road underdog.

There have been 60 upsets by teams that were 10 point underdogs or more in the 2022 regular season.
Out of 442 games with spreads of 10 or higher, 60 teams, or 13.57% were able to pull off the outright victory.